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Article

Inhibition of cardiac PERK signaling promotes peripartum cardiac dysfunction.

Scientific reports - 21 Sept 2021

Shimizu Takashi, Taguchi Akashi, Higashijima Yoshiki, Kanki Yasuharu, Nakaki Ryo, Urade Yoshihiro, Wada Youichiro

Abstract excerpt

Peripartum cardiomyopathy (PPCM) is a life-threatening heart failure occurring in the peripartum period. Although mal-angiogenesis, induced by the 16-kDa N-terminal prolactin fragment (16 K PRL), is involved in the pathogenesis, the effect of full-length prolactin (23 K PRL) is poorly understood. We transfected neonate rat cardiomyocytes with plasmids containing 23 K PRL or 16 K PRL in vitro and found that 23 K...

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Identifiers

PMID: 34548576
DOI: 10.1038/s41598-021-98344-7
PMCID: PMC8455649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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