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Article

Validating, augmenting and refining genome-wide association signals.

Nature reviews. Genetics - 1 May 2009

Ioannidis John P A, Thomas Gilles, Daly Mark J

Abstract excerpt

Studies using genome-wide platforms have yielded an unprecedented number of promising signals of association between genomic variants and human traits. This Review addresses the steps required to validate, augment and refine such signals to identify underlying causal variants for well-defined phenotypes. These steps include: large-scale exact replication across both similar and diverse populations; fine mapping...

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PMID: 19373277
DOI: 10.1038/nrg2544
PMCID: PMC7877552

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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