Article
Exploring the Pleiotropic Genes and Therapeutic Targets Associated with Heart Failure and Chronic Kidney Disease by Integrating metaCCA and SGLT2 Inhibitors' Target Prediction.
BioMed research international - 1 Jan 2021
Li Huanqiang, Mai Ziling, Yu Sijia, Wang Bo, Lai Wenguang, Chen Guanzhong, Zhou Chunyun, Liu Jin, Yang Yongquan, Chen Shiqun, Liu Yong, Chen Jiyan
Abstract excerpt
BACKGROUND: Previous studies have shown that heart failure (HF) and chronic kidney disease (CKD) have common genetic mechanisms, overlapping pathophysiological pathways, and therapeutic drug-sodium-glucose cotransporter 2 (SGLT2) inhibitors. METHODS: The genetic pleiotropy metaCCA method was applied on summary statistics data from two independent meta-analyses of GWAS comprising more than 1 million people to...
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