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Transgenic zebrafish expressing mutant human RETGC-1 exhibit aberrant cone and rod morphology.

Experimental eye research - 1 Mar 2013

Collery Ross F, Cederlund Maria L, Kennedy Breandán N

Abstract excerpt

Cone-rod dystrophy 6 (CORD6) is an inherited blindness that presents with defective cone photoreceptor function in childhood, followed by loss of rod function. CORD6 results from mutations in GUCY2D, the human gene encoding retinal guanylate cyclase 1 (RETGC-1). RETGC-1 functions in phototransduction, synthesising cGMP to open ion channels in photoreceptor outer segments. As there is limited histopathological...

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Animals, Genetically Modified
Guanylate Cyclase
Heterotrimeric GTP-Binding Proteins
Larva
Microinjections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Retinal Cone Photoreceptor Cells

Retinal Rod Photoreceptor Cells

Retinitis Pigmentosa

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PMID: 23328348
DOI: 10.1016/j.exer.2013.01.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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