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Article

Clinical validation of p16/Ki-67 dual-stained cytology triage of HPV-positive women: Results from the IMPACT trial.

International journal of cancer - 1 Feb 2022

Wright Thomas C, Stoler Mark H, Ranger-Moore Jim, Fang Qijun, Volkir Patrick, Safaeian Mahboobeh, Ridder Ruediger

Abstract excerpt

Triage strategies are needed for primary human papillomavirus (HPV)-based cervical cancer screening to identify women requiring colposcopy/biopsy. We assessed the performance of p16/Ki-67 dual-stained (DS) immunocytochemistry to triage HPV-positive women and compared it to cytology, with or without HPV16/18 genotyping. A prospective observational screening study enrolled 35 263 women aged 25 to 65 years at...

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Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Human papillomavirus 16

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Share to Uterine Cervical Neoplasms

Source

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Identifiers

PMID: 34536311
DOI: 10.1002/ijc.33812
PMCID: PMC9293341

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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