Comparison of HPV-positive triage strategies combining extended genotyping with cytology or p16/ki67 dual staining in the Italian NTCC2 study.

doi:10.1016/j.ebiom.2024.105149

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Article

Comparison of HPV-positive triage strategies combining extended genotyping with cytology or p16/ki67 dual staining in the Italian NTCC2 study.

EBioMedicine - 1 Jun 2024

Benevolo Maria, Ronco Guglielmo, Mancuso Pamela, Carozzi Francesca, De Marco Laura, Allia Elena, Bisanzi Simonetta, Rizzolo Raffaella, Gustinucci Daniela, Del Mistro Annarosa, Frayle Helena, Confortini Massimo, Viti Jessica, Iossa Anna, Cesarini Elena, Bulletti Simonetta, Passamonti Basilio, Gori Silvia, Toniolo Laura, Bonvicini Laura, Venturelli Francesco, Wentzensen Nicolas, Giorgi Rossi Paolo

Abstract excerpt

BACKGROUND: Each high-risk HPV genotype has different oncogenic potential, and the risk of CIN3+ varies according to genotype. We evaluated the performance of different strategies of HPV-positivity triage combining cytology, p16/ki67 dual staining (DS), and extended genotyping. METHODS: Samples from 3180 consecutive women from the NTCC2 study (NCT01837693) positive for HPV DNA at primary screening, were...

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Identifiers

PMID: 38759278
DOI: 10.1016/j.ebiom.2024.105149
PMCID: PMC11126882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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