Long-Term Prospective Cohort Study of Cervical Cancer Screening Using Triage of Women Who Are Human Papillomavirus-Positive With Dual Stain and Human Papillomavirus Genotyping.

doi:10.1200/JCO-25-00689

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Long-Term Prospective Cohort Study of Cervical Cancer Screening Using Triage of Women Who Are Human Papillomavirus-Positive With Dual Stain and Human Papillomavirus Genotyping.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Apr 2026

Wentzensen Nicolas, Egemen Didem, Clarke Megan A, Poitras Nancy, Grewal Kiranjit, Goldhoff Patricia, Hosfield Elizabeth, Schiffman Mark, Hyer Marianne, Castle Philip E, Fuller Laurie, Rydzak Greg, Cheung Li C, Kinney Walter, Suh-Burgmann Betty, Lorey Thomas

Abstract excerpt

PURPOSE: Primary human papillomavirus (HPV) testing has the best tradeoff of benefits and harms for cervical screening but requires triage to determine management among HPV positives. We conducted a prospective observational study to evaluate triage of women who are HPV-positive using dual stain (DS) and HPV genotyping. MATERIALS AND METHODS: We included 9,645 consecutive women who are HPV-positive undergoing...

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PMID: 41701950
DOI: 10.1200/JCO-25-00689
PMCID: PMC13537703

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