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Article

Interaction between Staphylococcus Agr virulence and neutrophils regulates pathogen expansion in the skin.

Cell host & microbe - 9 Jun 2021

Matsumoto Masanori, Nakagawa Seitaro, Zhang Lingzhi, Nakamura Yuumi, Villaruz Amer E, Otto Michael, Wolz Christiane, Inohara Naohiro, Núñez Gabriel

Abstract excerpt

Staphylococcus aureus commonly infects the skin, but the host-pathogen interactions controlling bacterial growth remain unclear. S. aureus virulence is regulated by the Agr quorum-sensing system that controls factors including phenol-soluble modulins (PSMs), a group of cytotoxic peptides. We found a differential requirement for Agr and PSMα for pathogen growth in the skin. In neutrophil-deficient mice, S. aureus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33852876
DOI: 10.1016/j.chom.2021.03.007
PMCID: PMC11024063

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