Increase of serum uric acid levels associated with APOE ε2 haplotype: a clinico-genetic investigation and in vivo approach.

doi:10.1007/s13577-021-00609-w

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Increase of serum uric acid levels associated with APOE ε2 haplotype: a clinico-genetic investigation and in vivo approach.

Human cell - 1 Nov 2021

Ogura Masatsune, Toyoda Yu, Sakiyama Masayuki, Kawamura Yusuke, Nakayama Akiyoshi, Yamanashi Yoshihide, Takada Tappei, Shimizu Seiko, Higashino Toshihide, Nakajima Mayuko, Naito Mariko, Hishida Asahi, Kawai Sayo, Okada Rieko, Sasaki Makoto, Ayaori Makoto, Suzuki Hiroshi, Takata Koki, Ikewaki Katsunori, Harada-Shiba Mariko, Shinomiya Nariyoshi, Matsuo Hirotaka

Abstract excerpt

Elevated serum uric acid (SUA)-hyperuricemia-is caused by overproduction of urate or by its decreased renal and/or intestinal excretion. This disease, which is increasing in prevalence worldwide, is associated with both gout and metabolic diseases. Several studies have reported relationships between apolipoprotein E (APOE) haplotypes and SUA levels in humans; however, their results remain inconsistent. This...

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PMID: 34532841
DOI: 10.1007/s13577-021-00609-w
PMCID: PMC8490264

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