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Role of pericytes in angiogenesis: focus on cancer angiogenesis and anti-angiogenic therapy

11 Jan 2016

Abstract excerpt

Pericytes, a kind of mural cells for microcirculation, are critical for vascular development and function. Although current studies indicate that PDGF/PDGFR-β, Ang/Tie2, TGF-β involve in the regulation of pericytes recruitment, the mechanisms governing pericytes migration and regulating angiogenesis, especially in cancers, have not been fully clear. Many evidences have showed that cancer vessels are characterized...

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PMID: 26774138
DOI: 10.4149/201_150704n369

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