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Article

How to treat histone 3 altered gliomas: molecular landscape and therapeutic developments.

Expert review of clinical pharmacology - 1 Jan 2023

Di Nunno Vincenzo, Franceschi Enrico, Gatto Lidia, Tosoni Alicia, Bartolini Stefania, Brandes Alba Ariela

Abstract excerpt

INTRODUCTION: Diffuse midline gliomas (DMG) and diffuse hemispheric glioma (DHG) are both rare tumors characterized and recognized for specific alterations of histone 3 including H3K27 (DMG) and H3G34 (DHG). Despite these tumors arising from alterations of the same gene their clinical, radiological, and molecular behaviors strongly diverge, requiring a personalized therapeutic approach. AREAS COVERED: We...

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PMID: 36576307
DOI: 10.1080/17512433.2023.2163385

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