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Article

Targeting chromosome trisomy for chromosome editing.

Scientific reports - 10 Sept 2021

Abe Takuya, Suzuki Yuya, Ikeya Teppei, Hirota Kouji

Abstract excerpt

A trisomy is a type of aneuploidy characterised by an additional chromosome. The additional chromosome theoretically accepts any kind of changes since it is not necessary for cellular proliferation. This advantage led us to apply two chromosome manipulation methods to autosomal trisomy in chicken DT40 cells. We first corrected chromosome 2 trisomy to disomy by employing counter-selection markers. Upon...

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Identifiers

PMID: 34508128
DOI: 10.1038/s41598-021-97580-1
PMCID: PMC8433146

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