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Article

Genomic editing of metformin efficacy-associated genetic variants in SLC47A1 does not alter SLC47A1 expression.

Human molecular genetics - 21 Feb 2022

Kalamajski Sebastian, Huang Mi, Dalla-Riva Jonathan, Keller Maria, Dawed Adem Y, Hansson Ola, Pearson Ewan R, Mulder Hindrik, Franks Paul W

Abstract excerpt

Several pharmacogenetics studies have identified an association between a greater metformin-dependent reduction in HbA1c levels and the minor A allele at rs2289669 in intron 10 of SLC47A1, encoding multidrug and toxin extrusion 1 (MATE1), a presumed metformin transporter. It is currently unknown if the rs2289669 locus is a cis-eQTL, which would validate its role as predictor of metformin efficacy. We looked at...

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Identifiers

PMID: 34505146
DOI: 10.1093/hmg/ddab266
PMCID: PMC8863414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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