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Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery

28 May 2021

Abstract excerpt

Non-Ribosomal Peptides (NRPs) represent a biomedically important class of natural products that include a multitude of antibiotics and other clinically used drugs. NRPs are not directly encoded in the genome but are instead produced by metabolic pathways encoded by biosynthetic gene clusters (BGCs). Since the existing genome mining tools predict many putative NRPs synthesized by a given BGC, it remains unclear...

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PMID: 34050176
DOI: 10.1038/s41467-021-23502-4

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