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Article

Leader peptide and a membrane protein scaffold guide the biosynthesis of the tricyclic peptide microviridin.

Chemistry & biology - 23 Nov 2011

Weiz Annika R, Ishida Keishi, Makower Katharina, Ziemert Nadine, Hertweck Christian, Dittmann Elke

Abstract excerpt

Microviridins are unique protease inhibitors from bloom-forming cyanobacteria that have both ecological and pharmacological relevance. Their peptide backbones are produced ribosomally, and ATP grasp ligases introduce ω-ester and ω-amide bonds to yield rare cage-like structures. Bioinformatic analysis of the microviridin biosynthesis gene cluster suggests a novel type of processing machinery, which could...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22118675
DOI: 10.1016/j.chembiol.2011.09.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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