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Article

The glucocorticoid receptor as a master regulator of the Müller cell response to diabetic conditions in mice

25 Jan 2024

Abstract excerpt

Diabetic retinopathy (DR) is considered a primarily microvascular complication of diabetes. Müller glia cells are at the centre of the retinal neurovascular unit and play a critical role in DR. We therefore investigated Müller cell-specific signalling pathways that are altered in DR to identify novel targets for gene therapy. Using a multi-omics approach on purified Müller cells from diabetic db/db mice, we found...

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PMID: 38273366
DOI: 10.1186/s12974-024-03021-x

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