How CEP164 ciliopathy mutations impair ciliogenesis.

doi:10.1016/j.str.2021.12.007

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

How CEP164 ciliopathy mutations impair ciliogenesis.

Structure (London, England : 1993) - 6 Jan 2022

Morrison Ciaran G

Abstract excerpt

CEP164 recruits TTBK2 to the distal end of centrioles to allow primary cilium formation. In this issue of Structure, Rosa e Silva et al. (2022) present co-crystallized structures that show the molecular basis of this recruitment and define how ciliopathy mutations in CEP164 disrupt the CEP164-TTBK2 complex.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Centrioles
Share to Cilia
Share to Ciliopathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Source

Open in PubMed

Identifiers

PMID: 34995479
DOI: 10.1016/j.str.2021.12.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

How CEP164 ciliopathy mutations impair ciliogenesis.PMID 34995479Read ↗

Molecular mechanisms underlying the role of the centriolar CEP164-TTBK2 complex in ciliopathies.Semantic proximity Read ↗

Biallelic variants in CEP164 cause a motile ciliopathy-like syndrome.Semantic proximity Read ↗

Disease-Associated Mutations in CEP120 Destabilize the Protein and Impair Ciliogenesis.Semantic proximity Read ↗

Binding to Cep164, but not EB1, is essential for centriolar localization of TTBK2 and its function in ciliogenesis.Semantic proximity Read ↗

The morbid genome of ciliopathies: an update.Semantic proximity Read ↗

CEP162 deficiency causes human retinal degeneration and reveals a dual role in ciliogenesis and neurogenesisSemantic proximity Read ↗

Making sense of cilia in disease: the human ciliopathies.Semantic proximity Read ↗

The ciliopathies: an emerging class of human genetic disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.