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Article

NOD/scid IL-2Rγnull mice reconstituted with peripheral blood mononuclear cells from patients with Crohn's disease reflect the human pathological phenotype.

Immunity, inflammation and disease - 1 Dec 2021

Unterweger Anna-Lena, Rüscher Alena, Seuß Marietta, Winkelmann Paula, Beigel Florian, Koletzko Leandra, Breiteneicher Simone, Siebeck Matthias, Gropp Roswitha, Aszodi Attila

Abstract excerpt

INTRODUCTION: Crohn's disease (CD) is characterized by pronounced intestinal fibrosis and severe mucosal damage and conventional animal models are limited to reflect these pathological manifestations. The aim of this study was to examine whether the combination of patient immune-profiling and preclinical studies in a mouse model based on NOD/scid IL-2Rγnull (NSG) reconstituted with peripheral blood mononuclear...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34499803
DOI: 10.1002/iid3.516
PMCID: PMC8589348

Genes

CD14
CD163
HGF
CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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