Article
Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report.
European journal of cancer (Oxford, England : 1990) - 1 May 2021
Seppälä Toni T, Dominguez-Valentin Mev, Crosbie Emma J, Engel Christoph, Aretz Stefan, Macrae Finlay, Winship Ingrid, Capella Gabriel, Thomas Huw, Hovig Eivind, Nielsen Maartje, Sijmons Rolf H, Bertario Lucio, Bonanni Bernardo, Tibiletti Maria G, Cavestro Giulia M, Mints Miriam, Gluck Nathan, Katz Lior, Heinimann Karl, Vaccaro Carlos A, Green Kate, Lalloo Fiona, Hill James, Schmiegel Wolff, Vangala Deepak, Perne Claudia, Strauß Hans-Georg, Tecklenburg Johanna, Holinski-Feder Elke, Steinke-Lange Verena, Mecklin Jukka-Pekka, Plazzer John-Paul, Pineda Marta, Navarro Matilde, Vida Joan B, Kariv Revital, Rosner Guy, Piñero Tamara A, Pavicic Walter, Kalfayan Pablo, Ten Broeke Sanne W, Jenkins Mark A, Sunde Lone, Bernstein Inge, Burn John, Greenblatt Marc, de Vos Tot Nederveen Cappel Wouter H, Della Valle Adriana, Lopez-Koestner Francisco, Alvarez Karin, Büttner Reinhard, Görgens Heike, Morak Monika, Holzapfel Stefanie, Hüneburg Robert, von Knebel Doeberitz Magnus, Loeffler Markus, Redler Silke, Weitz Jürgen, Pylvänäinen Kirsi, Renkonen-Sinisalo Laura, Lepistö Anna, Hopper John L, Win Aung K, Lindor Noralane M, Gallinger Steven, Le Marchand Loïc, Newcomb Polly A, Figueiredo Jane C, Thibodeau Stephen N, Therkildsen Christina, Wadt Karin A W, Mourits Marian J E, Ketabi Zohreh, Denton Oliver G, Rødland Einar A, Vasen Hans, Neffa Florencia, Esperon Patricia, Tjandra Douglas, Möslein Gabriela, Rokkones Erik, Sampson Julian R, Evans D G, Møller Pål
Abstract excerpt
PURPOSE: This study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecological cancers (risk-reducing surgery [RRS]) in carriers of pathogenic MMR (path_MMR) variants. METHODS: The Prospective Lynch Syndrome Database (PLSD) was used to investigate RRS by a cross-sectional study in 2292 female path_MMR carriers aged 30-69 years. RESULTS: Overall, 144, 79, and...
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