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Article

Evaluation of MTAP immunohistochemistry loss of expression in ovarian serous borderline tumors as a potential marker for prognosis and progression.

Annals of diagnostic pathology - 1 Oct 2020

Nilforoushan Neshat, Moatamed Neda A

Abstract excerpt

INTRODUCTION: Serous borderline tumors (SBT) are the most common subtype of ovarian borderline tumors with excellent clinical course. However, they can recur or progress to low-grade serous carcinoma (LGSC) in a small proportion of the cases. Beside BRAF and KRAS mutations, copy number alterations (CNA), particularly loss of chromosome 9p21 locus which results in deletion of genes CDKN2A and MTAP, have been...

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PMID: 32866902
DOI: 10.1016/j.anndiagpath.2020.151582

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