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Article

Allele-Specific Chemical Rescue of Histone Demethylases Using Abiotic Cofactors.

ACS chemical biology - 16 Dec 2022

Scott Valerie, Dey Debasis, Kuwik Jordan, Hinkelman Kathryn, Waldman Megan, Islam Kabirul

Abstract excerpt

Closely related protein families evolved from common ancestral genes present a significant hurdle in developing member- and isoform-specific chemical probes, owing to their similarity in fold and function. In this piece of work, we explore an allele-specific chemical rescue strategy to activate a "dead" variant of a wildtype protein using synthetic cofactors and demonstrate its successful application to the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34496208
DOI: 10.1021/acschembio.1c00335
PMCID: PMC10230450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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