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Development of Keratinocyte Cell Lines Containing Extrachromosomal Human Papillomavirus Genomes

1 Sept 2021

Abstract excerpt

Abstract Human papillomaviruses (HPVs) cause persistent infections in stratified cutaneous and mucosal epithelia. In these infections, the viral DNA replicates as low‐copy‐number, extrachromosomal, double‐stranded‐DNA circular plasmids in the nucleus of the dividing basal cells. When the infected cells begin the process of differentiation, the viral DNA amplifies to a high copy number and virions are assembled in...

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PMID: 34496149
DOI: 10.1002/cpz1.235

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