Article
3D Oral and Cervical Tissue Models for Studying Papillomavirus Host‐Pathogen Interactions
24 Nov 2020
Abstract excerpt
Human papillomavirus (HPV) infection occurs in differentiating epithelial tissues. Cancers caused by high-risk types (e.g., HPV16 and HPV18) typically occur at oropharyngeal and anogenital anatomical sites. The HPV life cycle is differentiation-dependent, requiring tissue culture methodology that is able to recapitulate the three-dimensional (3D) stratified epithelium. Here we report two distinct and...
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