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Fibroblasts regulate the transcriptional signature of human papillomavirus-positive keratinocytes

10 Dec 2024

Abstract excerpt

Persistent human papillomavirus (HPV) infection is necessary but insufficient for viral oncogenesis. Additional contributing co-factors, such as immune evasion and viral integration have been implicated in HPV-induced cancer progression. It is widely accepted that HPV + keratinocytes require co-culture with fibroblasts to maintain viral DNA as episomes. How fibroblasts regulate viral episome maintenance is a...

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PMID: 39667669
DOI: 10.1016/j.tvr.2024.200302

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