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Article

Unravelling the Shared Genetic Mechanisms Underlying 18 Autoimmune Diseases Using a Systems Approach.

Frontiers in immunology - 1 Jan 2021

Gokuladhas Sreemol, Schierding William, Golovina Evgeniia, Fadason Tayaza, O'Sullivan Justin

Abstract excerpt

Autoimmune diseases (AiDs) are complex heterogeneous diseases characterized by hyperactive immune responses against self. Genome-wide association studies have identified thousands of single nucleotide polymorphisms (SNPs) associated with several AiDs. While these studies have identified a handful of pleiotropic loci that confer risk to multiple AiDs, they lack the power to detect shared genetic factors residing...

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Identifiers

PMID: 34484189
DOI: 10.3389/fimmu.2021.693142
PMCID: PMC8415031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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