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USP5 Sustains the Proliferation of Glioblastoma Through Stabilization of CyclinD1

16 Aug 2021

Abstract excerpt

Glioblastoma multiforme (GBM) is one of the most malignant primary tumors in humans. Despite standard therapeutic strategy with tumor resection combined with radiochemotherapy, the prognosis remains disappointed. Recently, deubiquitinating enzymes (DUBs) has been reported as potential cancer therapy targets due to their multifunctions involved in the regulation of tumorigenesis, cell cycle, apoptosis, and...

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PMID: 34483932
DOI: 10.3389/fphar.2021.720307

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