Article
Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response.
Nature cancer - 1 Sept 2020
Poillet-Perez Laura, Sharp Daniel W, Yang Yang, Laddha Saurabh V, Ibrahim Maria, Bommareddy Praveen K, Hu Zhixian Sherrie, Vieth Joshua, Haas Michael, Bosenberg Marcus W, Rabinowitz Joshua D, Cao Jian, Guan Jun-Lin, Ganesan Shridar, Chan Chang S, Mehnert Janice M, Lattime Edmund C, White Eileen
Abstract excerpt
Macroautophagy (hereafter autophagy) degrades and recycles intracellular components to sustain metabolism and survival during starvation. Host autophagy promotes tumor growth by providing essential tumor nutrients. Autophagy also regulates immune cell homeostasis and function and suppresses inflammation. Although host autophagy does not promote a T-cell anti-tumor immune response in tumors with low tumor...
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