Article
Image-based assessment of extracellular mucin-to-tumor area predicts consensus molecular subtypes (CMS) in colorectal cancer.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 2022
Nguyen Huu-Giao, Lundström Oxana, Blank Annika, Dawson Heather, Lugli Alessandro, Anisimova Maria, Zlobec Inti
Abstract excerpt
The backbone of all colorectal cancer classifications including the consensus molecular subtypes (CMS) highlights microsatellite instability (MSI) as a key molecular pathway. Although mucinous histology (generally defined as >50% extracellular mucin-to-tumor area) is a "typical" feature of MSI, it is not limited to this subgroup. Here, we investigate the association of CMS classification and mucin-to-tumor area...
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