Article
Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning.
Gut - 1 Mar 2021
Sirinukunwattana Korsuk, Domingo Enric, Richman Susan D, Redmond Keara L, Blake Andrew, Verrill Clare, Leedham Simon J, Chatzipli Aikaterini, Hardy Claire, Whalley Celina M, Wu Chieh-Hsi, Beggs Andrew D, McDermott Ultan, Dunne Philip D, Meade Angela, Walker Steven M, Murray Graeme I, Samuel Leslie, Seymour Matthew, Tomlinson Ian, Quirke Phil, Maughan Timothy, Rittscher Jens, Koelzer Viktor H
Abstract excerpt
OBJECTIVE: Complex phenotypes captured on histological slides represent the biological processes at play in individual cancers, but the link to underlying molecular classification has not been clarified or systematised. In colorectal cancer (CRC), histological grading is a poor predictor of disease progression, and consensus molecular subtypes (CMSs) cannot be distinguished without gene expression profiling. We...
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