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Structural basis of P[II] rotavirus evolution and host ranges under selection of histo-blood group antigens

2 Sept 2021

Abstract excerpt

Group A rotaviruses cause severe gastroenteritis in infants and young children worldwide, with P[II] genogroup rotaviruses (RVs) responsible for >90% of global cases. RVs have diverse host ranges in different human and animal populations determined by host histo-blood group antigen (HBGA) receptor polymorphism, but details governing diversity, host ranges, and species barriers remain elusive. In this study,...

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PMID: 34475219
DOI: 10.1073/pnas.2107963118

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