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Article

Glycan recognition in globally dominant human rotaviruses.

Nature communications - 6 Jul 2018

Hu Liya, Sankaran Banumathi, Laucirica Daniel R, Patil Ketki, Salmen Wilhelm, Ferreon Allan Chris M, Tsoi Phoebe S, Lasanajak Yi, Smith David F, Ramani Sasirekha, Atmar Robert L, Estes Mary K, Ferreon Josephine C, Prasad B V Venkataram

Abstract excerpt

Rotaviruses (RVs) cause life-threatening diarrhea in infants and children worldwide. Recent biochemical and epidemiological studies underscore the importance of histo-blood group antigens (HBGA) as both cell attachment and susceptibility factors for the globally dominant P[4], P[6], and P[8] genotypes of human RVs. How these genotypes interact with HBGA is not known. Here, our crystal structures of P[4] and a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29980685
DOI: 10.1038/s41467-018-05098-4
PMCID: PMC6035239

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