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Article

Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection.

PLoS pathogens - 1 Sept 2021

Severa Martina, Diotti Roberta A, Etna Marilena P, Rizzo Fabiana, Fiore Stefano, Ricci Daniela, Iannetta Marco, Sinigaglia Alessandro, Lodi Alessandra, Mancini Nicasio, Criscuolo Elena, Clementi Massimo, Andreoni Massimo, Balducci Stefano, Barzon Luisa, Stefanelli Paola, Clementi Nicola, Coccia Eliana M

Abstract excerpt

SARS-CoV-2 fine-tunes the interferon (IFN)-induced antiviral responses, which play a key role in preventing coronavirus disease 2019 (COVID-19) progression. Indeed, critically ill patients show an impaired type I IFN response accompanied by elevated inflammatory cytokine and chemokine levels, responsible for cell and tissue damage and associated multi-organ failure. Here, the early interaction between SARS-CoV-2...

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Identifiers

PMID: 34473805
DOI: 10.1371/journal.ppat.1009878
PMCID: PMC8412261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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