Article
In silico analysis of mutations associated with occult hepatitis B virus (HBV) infection in South Africa.
Archives of virology - 1 Nov 2021
Olagbenro Matthew, Anderson Motswedi, Gaseitsiwe Simani, Powell Eleanor A, Gededzha Maemu P, Selabe Selokela G, Blackard Jason T
Abstract excerpt
Occult hepatitis B virus (OBI) infection is defined by the presence of viral DNA in the liver and/or serum in absence of hepatitis B surface antigen (HBsAg). While multiple studies have identified mutations that are associated with OBI, only a small portion of these mutations have been functionally characterized in vitro. Using complementary in silico approaches, the effects of OBI-associated amino acid mutations...
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