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Article

Gating pore currents occur in CaV1.1 domain III mutants associated with HypoPP.

The Journal of general physiology - 1 Nov 2021

Wu Fenfen, Quinonez Marbella, Cannon Stephen C

Abstract excerpt

Mutations in the voltage sensor domain (VSD) of CaV1.1, the α1S subunit of the L-type calcium channel in skeletal muscle, are an established cause of hypokalemic periodic paralysis (HypoPP). Of the 10 reported mutations, 9 are missense substitutions of outer arginine residues (R1 or R2) in the S4 transmembrane segments of the homologous domain II, III (DIII), or IV. The prevailing view is that R/X mutations...

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Share to Calcium Channels, L-Type
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Identifiers

PMID: 34463712
DOI: 10.1085/jgp.202112946
PMCID: PMC8563280

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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