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Article

Modulation of Malaria Phenotypes by Pyruvate Kinase (PKLR) Variants in a Thai Population.

PloS one - 1 Jan 2015

van Bruggen Rebekah, Gualtieri Christian, Iliescu Alexandra, Louicharoen Cheepsunthorn Chalisa, Mungkalasut Punchalee, Trape Jean-François, Modiano David, Sirima Bienvenu Sodiomon, Singhasivanon Pratap, Lathrop Mark, Sakuntabhai Anavaj, Bureau Jean-François, Gros Philippe

Abstract excerpt

Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. We have shown that Pklr deficiency in mice reduces the severity (reduced parasitemia, increased survival) of blood stage malaria induced by infection with Plasmodium chabaudi AS. Likewise, studies in human erythrocytes infected ex vivo with P. falciparum show that presence of host PK-deficiency alleles...

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Identifiers

PMID: 26658699
DOI: 10.1371/journal.pone.0144555
PMCID: PMC4677815

Genes

PKLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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