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Article

Malaria: looking for selection signatures in the human PKLR gene region.

British journal of haematology - 1 Jun 2010

Machado Patrícia, Pereira Rui, Rocha Ana Mafalda, Manco Licínio, Fernandes Natércia, Miranda Juliana, Ribeiro Letícia, do Rosário Virgílio E, Amorim António, Gusmão Leonor, Arez Ana Paula

Abstract excerpt

The genetic component of susceptibility to malaria is both complex and multigenic and the better-known protective polymorphisms are those involving erythrocyte-specific structural proteins and enzymes. In vivo and in vitro data have suggested that pyruvate kinase deficiency, which causes a nonspherocytic haemolytic anaemia, could be protective against malaria severity in humans, but this hypothesis remains to be...

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Source

Identifiers

PMID: 20377593
DOI: 10.1111/j.1365-2141.2010.08165.x

Genes

PKLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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