Article
Diagnosis and management of an endometrial cancer patient with Cowden syndrome.
Gynecologic oncology - 1 Oct 2021
Manning-Geist Beryl L, Gatius Sonia, Liu Ying, Gil Mabel, Da Cruz Paula Arnaud, Tuset Noemi, Abu-Rustum Nadeem R, Aghajanian Carol, Weigelt Britta, Matias-Guiu Xavier
Abstract excerpt
Somatic PTEN alterations are common in endometrial carcinoma (EC), but in rare cases PTEN mutations are associated with inherited syndromes. Here, we present a case of Cowden syndrome-associated EC. We discuss clinical, pathologic and molecular features of her tumor and PTEN-mutated EC, inherited syndromes predisposing to EC and PTEN-targeted therapies.
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