Second malignant neoplasms in patients with Cowden syndrome with underlying germline PTEN mutations.

Abstract excerpt

PURPOSE: Patients with Cowden syndrome (CS) with underlying germline PTEN mutations are at increased risk of breast, thyroid, endometrial, and renal cancers. To our knowledge, risk of subsequent cancers in these patients has not been previously explored or quantified. PATIENTS AND METHODS: We conducted a 7-year multicenter prospective study (2005 to 2012) of patients with CS or CS-like disease, all of whom...

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