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Article

Proinflammatory Pathways Are Activated in the Human Q344X Rhodopsin Knock-In Mouse Model of Retinitis Pigmentosa.

Biomolecules - 6 Aug 2021

Hollingsworth T J, Hubbard Meredith G, Levi Hailey J, White William, Wang Xiangdi, Simpson Raven, Jablonski Monica M, Gross Alecia K

Abstract excerpt

Retinitis pigmentosa (RP) is a hereditary disease of the retina that results in complete blindness. Currently, there are very few treatments for the disease and those that exist work only for the recessively inherited forms. To better understand the pathogenesis of RP, multiple mouse models have been generated bearing mutations found in human patients including the human Q344X rhodopsin knock-in mouse. In recent...

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Identifiers

PMID: 34439829
DOI: 10.3390/biom11081163
PMCID: PMC8393353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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