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Article

Evaluation of Multivalent Sialylated Polyglycerols for Resistance Induction in and Broad Antiviral Activity against Influenza A Viruses.

Journal of medicinal chemistry - 9 Sept 2021

Stadtmueller Marlena N, Bhatia Sumati, Kiran Pallavi, Hilsch Malte, Reiter-Scherer Valentin, Adam Lutz, Parshad Badri, Budt Matthias, Klenk Simon, Sellrie Katrin, Lauster Daniel, Seeberger Peter H, Hackenberger Christian P R, Herrmann Andreas, Haag Rainer, Wolff Thorsten

Abstract excerpt

The development of multivalent sialic acid-based inhibitors active against a variety of influenza A virus (IAV) strains has been hampered by high genetic and structural variability of the targeted viral hemagglutinin (HA). Here, we addressed this challenge by employing sialylated polyglycerols (PGs). Efficacy of prototypic PGs was restricted to a narrow spectrum of IAV strains. To understand this restriction, we...

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Identifiers

PMID: 34432457
DOI: 10.1021/acs.jmedchem.1c00794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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