Article
Fibroblast growth factor 21 and grow differentiation factor 15 are sensitive biomarkers of mitochondrial diseases due to mitochondrial transfer-RNA mutations and mitochondrial DNA deletions.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Dec 2020
Formichi Patrizia, Cardone Nastasia, Taglia Ilaria, Cardaioli Elena, Salvatore Simona, Gerfo Annalisa Lo, Simoncini Costanza, Montano Vincenzo, Siciliano Gabriele, Mancuso Michelangelo, Malandrini Alessandro, Federico Antonio, Dotti Maria Teresa
Abstract excerpt
BACKGROUND: Diagnosis of mitochondrial diseases (MDs) is challenging, since they are multisystemic disorders, characterized by a heterogeneous symptomatology. Recently, an increase in serum levels of fibroblast growth factor 21 (FGF21) and growth differentiation factor 15 (GDF15) has been found in the majority of patients with MDs compared with healthy controls. On the other hand, the finding of low FGF21 and...
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