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Article

Effects of EPHX1, SCN1A and CYP3A4 genetic polymorphisms on plasma carbamazepine concentrations and pharmacoresistance in Chinese patients with epilepsy.

Epilepsy research - 1 Dec 2013

Yun Wenting, Zhang Feng, Hu Cheng, Luo Xiaopei, Xue Peng, Wang Jing, Ge Yubin, Meng Hongmei, Guo Yingjie

Abstract excerpt

The pharmacokinetics and pharmacodynamics of carbamazepine (CBZ) vary widely among patients with epilepsy. In this study, we sought to investigate the effects of genetic polymorphisms of the microsomal epoxide hydrolase (EPHX1), the sodium channel α subunit type I (SCN1A) and the cytochrome P450 3A4 (CYP3A4) genes on plasma CBZ concentrations and pharmacoresistance in Chinese patients with epilepsy. The EPHX1...

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Identifiers

PMID: 24125961
DOI: 10.1016/j.eplepsyres.2013.09.011

Genes

EPHX1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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