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Article

CD4+ T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope

19 Aug 2021

Abstract excerpt

Löfgren's syndrome (LS) is an acute form of sarcoidosis characterized by a genetic association with HLA-DRB1*03 (HLA-DR3) and an accumulation of CD4+ T cells of unknown specificity in the bronchoalveolar lavage (BAL). Here, we screened related LS-specific TCRs for antigen specificity and identified a peptide derived from NAD-dependent histone deacetylase hst4 (NDPD) of Aspergillus nidulans that stimulated these...

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PMID: 34410304
DOI: 10.1084/jem.20210785

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