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Elevated serum angiotensin converting enzyme correlates with specific HLA-DRB1 alleles and extrapulmonary manifestations in sarcoidosis.

Respiratory medicine and research - 1 Nov 2024

Rossides Marios, Megadimou Vasiliki, Smed-Sörensen Anna, Eklund Anders, Kullberg Susanna, Darlington Pernilla

Abstract excerpt

BACKGROUND: Genetics influence the clinical picture in sarcoidosis, a granulomatous heterogeneous disease often accompanied by elevated serum angiotensin converting enzyme (s-ACE). We aimed to investigate if certain HLA-DRB1 alleles correlate with the levels of s-ACE, known as a marker of the granuloma burden. METHODS: Medical journals of patients with sarcoidosis from a Swedish clinical registry were...

Topics

Humans
HLA-DRB1 Chains
Peptidyl-Dipeptidase A
Female
Retrospective Studies
Male
Sarcoidosis
Middle Aged
Adult
Alleles
Sweden

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PMID: 39393304
DOI: 10.1016/j.resmer.2024.101142

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