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Article

Purine Metabolism-Related Pathogenic Genes in Trigeminal Neuralgia: A Multiomics Mendelian Randomization Study.

Pain research & management - 1 Jan 2026

Shen Simin, Li Jiyan, Liu Zheng, Zhang Xili, Li Xiangming, Li Peiyao, Liu Yaping, Yuan Libiao, He Ying, Huang Zhangxiang

Abstract excerpt

PURPOSE: To investigate the association between purine metabolism-related genes and trigeminal neuralgia (TN) using multiomics approaches. METHODS: A multiomics summary-data-based Mendelian randomization (SMR) approach was applied to investigate associations between purine metabolism-related genes and TN. Genome-wide association study (GWAS) data from FinnGen R10 were integrated with blood-derived DNA methylation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42563458
DOI: 10.1155/prm/1640039
PMCID: PMC13448146

Genes

CNOT7
PLAT
ATP6V0E2
VKORC1
ABCB1
COMT
GFM1
MDH2
NRAS
POMGNT2
TXN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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