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Article

Phenotypic characterization of two novel cell line models of castration-resistant prostate cancer.

The Prostate - 1 Nov 2021

Haffner Michael C, Bhamidipati Akshay, Tsai Harrison K, Esopi David M, Vaghasia Ajay M, Low Jin-Yih, Patel Radhika A, Guner Gunes, Pham Minh-Tam, Castagna Nicole, Hicks Jessica, Wyhs Nicolas, Aebersold Ruedi, De Marzo Angelo M, Nelson William G, Guo Tiannan, Yegnasubramanian Srinivasan

Abstract excerpt

BACKGROUND: Resistance to androgen deprivation therapies is a major driver of mortality in advanced prostate cancer. Therefore, there is a need to develop new preclinical models that allow the investigation of resistance mechanisms and the assessment of drugs for the treatment of castration-resistant prostate cancer. METHODS: We generated two novel cell line models (LAPC4-CR and VCaP-CR) which were derived by...

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Identifiers

PMID: 34402095
DOI: 10.1002/pros.24210
PMCID: PMC8460612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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