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Article

AURKB promotes tumorigenesis and carboplatin resistance by regulating the ERK pathway in neuroblastoma cells

16 Aug 2021

Abstract excerpt

BACKGROUND: Previous research has revealed that activation or aberrant expression of kinases can lead to tumorigenesis of various cancers, including neuroblastoma (NB). Suppression of kinase expression can reduce drug resistance. We explored the potential role and mechanism of the aurora kinase B (AURKB) gene in the acquisition of carboplatin resistance in NB. METHODS: Immunohistochemistry (IHC) and qRT-PCR were...

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PMID: 34396896
DOI: 10.1080/00207454.2021.1914610

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