Article

Impaired bone strength and bone microstructure in a novel early-onset osteoporotic rat model with a clinically relevant <i>PLS3</i> mutation

2022-07-02

Abstract excerpt

Osteoporosis is a highly prevalent disorder with a strong genetic component. Recent studies identify PLS3 as a novel bone regulator of bone metabolism and PLS3 mutations lead to a rare monogenic early-onset osteoporosis. However, the mechanism of PLS3 mutation leading to osteoporosis is unknown with no animal models carrying patient-derived PLS3 mutations generated. The effective treatment strategies for PLS3...

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Literature Corpus work: beb715e2-af14-5fb1-8231-a4991dcbc38d
DOI: 10.1101/2022.06.29.498081

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