Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protracted yet Coordinated Differentiation of Long-Lived SARS-CoV-2-Specific CD8+ T Cells during Convalescence

13 Aug 2021

Abstract excerpt

Abstract CD8+ T cells can potentiate long-lived immunity against COVID-19. We screened longitudinally-sampled convalescent human donors against SARS-CoV-2 tetramers and identified a participant with an immunodominant response against residues 322 to 311 of nucleocapsid (Nuc322–331), a peptide conserved in all variants of concern reported to date. We conducted 38-parameter cytometry by time of flight on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immunotherapy and Immune Responses
Share to SARS-CoV-2 and COVID-19 Research
Share to vaccines and immunoinformatics approaches

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34389625
DOI: 10.4049/jimmunol.2100465

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protracted yet Coordinated Differentiation of Long-Lived SARS-CoV-2-Specific CD8+ T Cells during ConvalescencePMID 34389625Read ↗

Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19Semantic proximity Read ↗

SARS-CoV-2-specific CD8+ T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over 2 years.Semantic proximity Read ↗

Rapid, simplified whole blood-based multiparameter assay to quantify and phenotype SARS-CoV-2-specific T-cells.Semantic proximity Read ↗

T Cell Dynamics in COVID-19, Long COVID and Successful RecoverySemantic proximity Read ↗

Immune Features of COVID-19 Convalescent Individuals Revealed by a Single-cell RNA SequencingSemantic proximity Read ↗

The characterization of CD8 + T-cell responses in COVID-19Semantic proximity Read ↗

Comprehensive longitudinal profiling of SARS-CoV-2-specific CD8 <sup>+</sup> T-cells reveal strong functional impairment and recognition bias as markers for disease severitySemantic proximity Read ↗

High and Sustained Ex Vivo Frequency but Altered Phenotype of SARS-CoV-2-Specific CD4+ T-Cells in an Anti-CD20-Treated Patient with Prolonged COVID-19.Semantic proximity Read ↗

Low avidity circulating SARS-CoV-2 reactive CD8+ T cells with proinflammatory TEMRA phenotype are associated with post-acute sequelae of COVID-19Semantic proximity Read ↗

Dysfunctional Sars-CoV-2-M protein-specific cytotoxic T lymphocytes in patients recovering from severe COVID-19Semantic proximity Read ↗

Durability of SARS-CoV-2-specific T cell responses at 12-months post-infectionSemantic proximity Read ↗

A unique cytotoxic CD4 + T cell‐signature defines critical COVID‐19Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.