Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A broadly active fucosyltransferase LmjFUT1 whose mitochondrial localization and activity are essential in parasitic Leishmania.

Proceedings of the National Academy of Sciences of the United States of America - 17 Aug 2021

Guo Hongjie, Damerow Sebastian, Penha Luciana, Menzies Stefanie, Polanco Gloria, Zegzouti Hicham, Ferguson Michael A J, Beverley Stephen M

Abstract excerpt

Glycoconjugates play major roles in the infectious cycle of the trypanosomatid parasite Leishmania While GDP-Fucose synthesis is essential, fucosylated glycoconjugates have not been reported in Leishmania major [H. Guo et al., J. Biol. Chem. 292, 10696-10708 (2017)]. Four predicted fucosyltransferases appear conventionally targeted to the secretory pathway; SCA1/2 play a role in side-chain modifications of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Culture Media
Share to Fucosyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Galactoside 2-alpha-L-fucosyltransferase

Share to Gene Expression Regulation, Enzymologic

Share to Leishmania major

Share to Mitochondria

Share to Protein Transport

Share to Protozoan Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 34385330
DOI: 10.1073/pnas.2108963118
PMCID: PMC8379939

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A broadly active fucosyltransferase LmjFUT1 whose mitochondrial localization and activity are essential in parasitic Leishmania.PMID 34385330Read ↗

A broadly active fucosyltransferase <i>LmjFUT1</i> whose mitochondrial localization and catalytic activity is essential in the parasitic protozoan <i>Leishmania</i>Semantic proximity Read ↗

An expanded proteomic survey of the human parasite <i>Leishmania major</i> focusing on changes in null mutants of the Golgi GDP-Mannose/Fucose/Arabino <i>pyranose</i> transporter <i>LPG2</i> or the mitochondrial fucosyltransferase <i>FUT1</i>Semantic proximity Read ↗

Glycoprotein biosynthesis in a eukaryote lacking the membrane protein Rft1.Semantic proximity Read ↗

Identification and structural analysis of a novel FUT1 c.789C>A variant and previously reported para-Bombay alleles using an α2FucT1 structural model.Semantic proximity Read ↗

Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hostsSemantic proximity Read ↗

Two Functionally Divergent UDP-Gal Nucleotide Sugar Transporters Participate in Phosphoglycan Synthesis in Leishmania majorSemantic proximity Read ↗

Identification and functional characterization of a highly divergent N-acetylglucosaminyltransferase I (TbGnTI) in Trypanosoma brucei.Semantic proximity Read ↗

Comparative genomics of Leishmania (Mundinia)Semantic proximity Read ↗

Molecular diversity of the Trypanosoma cruzi TcSMUG family of mucin genes and proteins.Semantic proximity Read ↗

Regulation and biological function of a flagellar glucose transporter in Leishmania mexicana: a potential glucose sensor.Semantic proximity Read ↗

A non-Golgi alpha 1,2-fucosyltransferase that modifies Skp1 in the cytoplasm of Dictyostelium.Semantic proximity Read ↗

Evolutionary adaptation in fucosyllactose uptake systems supports bifidobacteria-infant symbiosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.